Metabolism Alprazolam is thoroughly metabolized in people, primarily by cytochrome P450 3A4 (CYP3A4), to 2 major Lively metabolites from the plasma: four-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation amounts of the two Lively metabolites are a lot less than 4% from the father or mother. The noted relative potencies in benzodiaze